Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds

Lopa V. Desai; Kami L. Hull; Melanie S. Sanford

doi:10.1021/ja046831c

Palladium-catalyzed oxygenation of unactivated sp³ C-H bonds

Lopa V. Desai, Kami L. Hull, Melanie S. Sanford

Research output: Contribution to journal › Article › peer-review

Abstract

This communication describes a new palladium-catalyzed method for the oxygenation of unactivated sp³ C-H bonds. A wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups are oxidized with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity. The substrate scope of these reactions is discussed, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates.

Original language	English (US)
Pages (from-to)	9542-9543
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	31
DOIs	https://doi.org/10.1021/ja046831c
State	Published - Aug 11 2004
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Online availability

10.1021/ja046831c

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