Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds

Lopa V. Desai, Kami Lee Hull, Melanie S. Sanford

Research output: Contribution to journalArticlepeer-review

Abstract

This communication describes a new palladium-catalyzed method for the oxygenation of unactivated sp3 C-H bonds. A wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups are oxidized with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity. The substrate scope of these reactions is discussed, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates.

Original languageEnglish (US)
Pages (from-to)9542-9543
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number31
DOIs
StatePublished - Aug 11 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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