Palladium-Catalyzed Dearomative syn-1,4-Oxyamination

Conghui Tang, Mikiko Okumura, Hejun Deng, David Sarlah

Research output: Contribution to journalArticle

Abstract

A palladium-catalyzed dearomative syn-1,4-oxyamination protocol using non-activated arenes has been developed. This one-pot procedure utilizes arenophile chemistry, and the corresponding para-cycloadducts are treated with oxygen nucleophiles via formal allylic substitution, providing direct access to syn-1,4-oxyaminated products. The reaction conditions permit a range of arenes, as well as different O-nucleophiles, such as oximes and benzyl alcohols. Moreover, this process was established in an asymmetric fashion, delivering products with high enantioselectivity. The dearomatized products are amenable to a multitude of further derivatizations ranging from olefin chemistry to C−H activation, giving rise to a diverse set of new functionalities. Overall, this dearomative functionalization offers rapid and controlled formation of molecular complexity, enabling straightforward access to functionalized small molecules from simple and readily available arenes.

Original languageEnglish (US)
Pages (from-to)15762-15766
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number44
DOIs
StatePublished - Oct 28 2019

Keywords

  • arene
  • arenophile
  • dearomatization
  • oxyamination
  • photochemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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