Abstract
(Chemical Equation Presented) Paclitaxel-polylactide nanoconjugates were prepared by the site-specific polymerization of lactide mediated by a paclitaxel-metal complex followed by nanoprecipitation (see scheme). The resulting nanoconjugates have nearly 100% paclitaxel incorporation efficiencies and predefined drug loadings, and are less than 100 nm in diameter. The drug burst release effect is completely eliminated with this drug delivery vehicle.
Original language | English (US) |
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Pages (from-to) | 4830-4834 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 26 |
DOIs | |
State | Published - Jun 16 2008 |
Externally published | Yes |
Keywords
- Drug delivery
- Nanoparticles
- Nanotechnology
- Polymer-drug conjugates
- Ring-opening polymerization
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Medicine(all)