Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles

Rong Tong, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Paclitaxel-polylactide nanoconjugates were prepared by the site-specific polymerization of lactide mediated by a paclitaxel-metal complex followed by nanoprecipitation (see scheme). The resulting nanoconjugates have nearly 100% paclitaxel incorporation efficiencies and predefined drug loadings, and are less than 100 nm in diameter. The drug burst release effect is completely eliminated with this drug delivery vehicle.

Original languageEnglish (US)
Pages (from-to)4830-4834
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number26
DOIs
StatePublished - Jun 16 2008

Keywords

  • Drug delivery
  • Nanoparticles
  • Nanotechnology
  • Polymer-drug conjugates
  • Ring-opening polymerization

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

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