Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles

Rong Tong; Jianjun Cheng

doi:10.1002/anie.200800491

Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles

Rong Tong, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Paclitaxel-polylactide nanoconjugates were prepared by the site-specific polymerization of lactide mediated by a paclitaxel-metal complex followed by nanoprecipitation (see scheme). The resulting nanoconjugates have nearly 100% paclitaxel incorporation efficiencies and predefined drug loadings, and are less than 100 nm in diameter. The drug burst release effect is completely eliminated with this drug delivery vehicle.

Original language	English (US)
Pages (from-to)	4830-4834
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	26
DOIs	https://doi.org/10.1002/anie.200800491
State	Published - Jun 16 2008
Externally published	Yes

Keywords

Drug delivery
Nanoparticles
Nanotechnology
Polymer-drug conjugates
Ring-opening polymerization

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Medicine(all)

Online availability

10.1002/anie.200800491

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KW - Nanotechnology

KW - Polymer-drug conjugates

KW - Ring-opening polymerization

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Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles

Abstract

Keywords

ASJC Scopus subject areas

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