P450s in plants, insects, and their fungal pathogens

Research output: Chapter in Book/Report/Conference proceedingChapter


Plants, insects, and fungal pathogens utilize numerous P450s in their biosynthetic and detoxicative pathways that provide the basis for their growth, development, and defense mechanisms. With many of their genes and enzymatic functions remaining to be characterized, this chapter details both those identified with functions in basic metabolic processes conserved among species and those with functions in metabolic and catabolic processes specific to individual species. Discussions of those in plants detail their unusually large numbers of P450 genes and atypical monooxygenase reactivities; discussions of those in insects detail their more limited numbers of P450 genes and typical monooxygenase reactivities; discussions of those in fungal pathogens detail only the very few characterized as involved in their interactions with plants and insects. In enumerating this collection of plant, insect, and fungal P450s, this chapter seeks to highlight the many molecular, biochemical, and computational tools available for future functional characterizations and biotechnological applications.

Original languageEnglish (US)
Title of host publicationCytochrome P450
Subtitle of host publicationStructure, Mechanism, and Biochemistry, Fourth Edition
Number of pages41
ISBN (Electronic)9783319121086
ISBN (Print)9783319121079
StatePublished - Jan 1 2015


  • Alkaloid
  • Brassinosteroid
  • CYP71
  • CYP72
  • CYP85
  • CYP86
  • Clan
  • Electron transfer partner
  • Furanocoumarin
  • Gene cluster
  • Gene conservation
  • Gene count
  • Genomic
  • Insect
  • P450 Fungal pathogen
  • P450 Plant
  • Phenylpropanoid
  • Signaling
  • Structural region
  • Synthetic pathway
  • Terpenoid

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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