P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors

Raju Subramanian, Divesh Aidasani, Keith Bailey, Dan Branstetter, Nancy Everds, Jian Jiang, Mark H. Norman, Ronya Primack, Gary L. Skiles, Irene Soto, Markian M. Stec, Mylo Wagner, Tian Wu, Xiaochun Zhu, Hervé Lebrec

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