P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

You Li; Min Liu; Lin Feng Chen; Ruichuan Chen

doi:10.1080/21541264.2017.1281864

P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

You Li, Min Liu, Lin Feng Chen, Ruichuan Chen

Research output: Contribution to journal › Review article › peer-review

Abstract

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

Original language	English (US)
Pages (from-to)	88-94
Number of pages	7
Journal	Transcription
Volume	9
Issue number	2
DOIs	https://doi.org/10.1080/21541264.2017.1281864
State	Published - Mar 15 2018

Keywords

7SK snRNP
Brd4
KAP1
P-TEFb
RNA Pol II
SEC
promoter-proximal pausing
transcription elongation

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2017.1281864

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abstract = "The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.",

keywords = "7SK snRNP, Brd4, KAP1, P-TEFb, RNA Pol II, SEC, promoter-proximal pausing, transcription elongation",

author = "You Li and Min Liu and Chen, {Lin Feng} and Ruichuan Chen",

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AU - Liu, Min

AU - Chen, Lin Feng

AU - Chen, Ruichuan

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Y1 - 2018/3/15

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AB - The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

KW - 7SK snRNP

KW - Brd4

KW - KAP1

KW - P-TEFb

KW - RNA Pol II

KW - SEC

KW - promoter-proximal pausing

KW - transcription elongation

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P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

Abstract

Keywords

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