P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

You Li, Min Liu, Lin Feng Chen, Ruichuan Chen

Research output: Contribution to journalReview article

Abstract

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalTranscription
Volume9
Issue number2
DOIs
StatePublished - Mar 15 2018

Keywords

  • 7SK snRNP
  • Brd4
  • KAP1
  • P-TEFb
  • RNA Pol II
  • SEC
  • promoter-proximal pausing
  • transcription elongation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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