Oxysterols and nuclear receptors

Liqian Ma, Erik Nelson

Research output: Contribution to journalReview article

Abstract

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X receptors. Oxysterols are also known to be ligands for the RAR-related orphan receptors, involved in normal T cell differentiation. However, increasing evidence supports a role for oxysterols in the progression of several diseases. Here, we review recent developments in oxysterol research, highlighting the biological functions that oxysterols exert through their target nuclear receptors: the liver X receptors, estrogen receptors, RAR-related orphan receptors and the glucocorticoid receptor. We also bring the regulation of the immune system into the context of interaction between oxysterols and nuclear receptors, discussing the effect of such interaction on the pro-inflammatory function of macrophages and the development of T cells. Finally, we examine the impact that oxysterols have on various disease models, including cancer, Alzheimer's disease and atherosclerosis, stressing the role of nuclear receptors if previously identified. This review underscores the need to consider the multifaceted roles of oxysterols in terms of multiple receptor engagements and selective modulation of these receptors.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume484
DOIs
StatePublished - Mar 15 2019

Fingerprint

Cytoplasmic and Nuclear Receptors
T-cells
Liver
Cholesterol
Ligands
Macrophages
Immune system
Glucocorticoid Receptors
Metabolism
Estrogen Receptors
T-Lymphocytes
Modulation
Derivatives
oxysterol binding protein
Oxysterols
Liver X Receptors
Disease Progression
Cell Differentiation
Immune System
Atherosclerosis

Keywords

  • 27-Hydroxycholesterol
  • Breast cancer
  • Cholesterol
  • Estrogen receptor
  • Liver x receptor
  • Oxysterol
  • Selective estrogen receptor modulator
  • Selective nuclear receptor modulator

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Oxysterols and nuclear receptors. / Ma, Liqian; Nelson, Erik.

In: Molecular and Cellular Endocrinology, Vol. 484, 15.03.2019, p. 42-51.

Research output: Contribution to journalReview article

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