Oxygen Starvation Unmasks a Killer

Riley L. Svec, Paul Hergenrother

Research output: Contribution to journalShort survey

Abstract

In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors. In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.

Original languageEnglish (US)
Pages (from-to)1313-1314
Number of pages2
JournalCell chemical biology
Volume25
Issue number11
DOIs
StatePublished - Nov 15 2018

Fingerprint

Starvation
Biological Products
Bearings (structural)
Oxygen
Prodrugs
Cell death
Cell Biology
Tumors
Cell Death
Switches
Neoplasms
Hypoxia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Oxygen Starvation Unmasks a Killer. / Svec, Riley L.; Hergenrother, Paul.

In: Cell chemical biology, Vol. 25, No. 11, 15.11.2018, p. 1313-1314.

Research output: Contribution to journalShort survey

Svec, Riley L. ; Hergenrother, Paul. / Oxygen Starvation Unmasks a Killer. In: Cell chemical biology. 2018 ; Vol. 25, No. 11. pp. 1313-1314.
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