Oxygen Starvation Unmasks a Killer

Riley L. Svec, Paul Hergenrother

Research output: Contribution to journalShort survey

Abstract

In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors. In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.

Original languageEnglish (US)
Pages (from-to)1313-1314
Number of pages2
JournalCell chemical biology
Volume25
Issue number11
DOIs
StatePublished - Nov 15 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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