TY - GEN
T1 - Oxidation of antibiotics with KMnO4
T2 - Water Quality Technology Conference and Exposition 2009
AU - Hu, Lanhua
AU - Martin, Heather M.
AU - Wammer, Kristine
AU - Stemig, Amanda
AU - Strathmann, Timothy J.
PY - 2009
Y1 - 2009
N2 - Several recent reports have documented the presence of antibiotics in drinking water sources, the result of incomplete treatment of waste streams originating from municipal sources and livestock operations. Although these compounds are detected at sub-therapeutic levels, their presence raises concerns about ecotoxicological and public health risks associated with long-term exposure. As a result, there is also growing interest in the fate of antibiotics during drinking water treatment processes. Potassium permanganate (KMnO 4) is used by a number of utilities to address a range of issues (e.g., dissolved Mn, T&O), but little is known about the effectiveness of KMnO4 for oxidizing antibiotics or the effect of treatment on antibiotic potency of the treated water. This contribution reports for the first time on treatment of commonly detected antibiotics (trimethoprim, lincomysin, ciprofloxacin, sulfamethoxazole, sulfamethizole, and chlortetracycline) with KMnO4. Kinetic studies demonstrate that KMnO4 is a selective oxidant, exhibiting apparent second-order rate constants with the target antibiotics at pH 7 ranging from <0.03 to 110 M-1 s -1. Reaction rates are highly dependent on pH, and measured kinetic trends can be modeled by accounting for changes in acid/base speciation of the target antibiotics. Kinetic model predictions also agree closely with measurements of antibiotic treatment in drinking water utility source waters of variable composition. Bioassay experiments show that oxidation products and intermediates possess negligible antibacterial activity in comparison with the parent drugs. 2009
AB - Several recent reports have documented the presence of antibiotics in drinking water sources, the result of incomplete treatment of waste streams originating from municipal sources and livestock operations. Although these compounds are detected at sub-therapeutic levels, their presence raises concerns about ecotoxicological and public health risks associated with long-term exposure. As a result, there is also growing interest in the fate of antibiotics during drinking water treatment processes. Potassium permanganate (KMnO 4) is used by a number of utilities to address a range of issues (e.g., dissolved Mn, T&O), but little is known about the effectiveness of KMnO4 for oxidizing antibiotics or the effect of treatment on antibiotic potency of the treated water. This contribution reports for the first time on treatment of commonly detected antibiotics (trimethoprim, lincomysin, ciprofloxacin, sulfamethoxazole, sulfamethizole, and chlortetracycline) with KMnO4. Kinetic studies demonstrate that KMnO4 is a selective oxidant, exhibiting apparent second-order rate constants with the target antibiotics at pH 7 ranging from <0.03 to 110 M-1 s -1. Reaction rates are highly dependent on pH, and measured kinetic trends can be modeled by accounting for changes in acid/base speciation of the target antibiotics. Kinetic model predictions also agree closely with measurements of antibiotic treatment in drinking water utility source waters of variable composition. Bioassay experiments show that oxidation products and intermediates possess negligible antibacterial activity in comparison with the parent drugs. 2009
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M3 - Conference contribution
AN - SCOPUS:84873506066
SN - 9781615679591
T3 - Water Quality Technology Conference and Exposition 2009
SP - 2357
EP - 2367
BT - Water Quality Technology Conference and Exposition 2009
Y2 - 15 November 2009 through 19 November 2009
ER -