Ovulation: Parallels with inflammatory processes

Diane M. Duffy, CheMyong Ko, Misung Jo, Mats Brannstrom, Thomas E. Curry

Research output: Contribution to journalReview article

Abstract

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes. These mediators, in turn, activate both nonimmune ovarian cells as well as resident immune cells within the ovary; additional immune cells are also attracted to the ovary. Collectively, these cells regulate proteolytic pathways to reorganize the follicular stroma, disrupt the granulosa cell basal lamina, and facilitate invasion of vascular endothelial cells. LH-induced mediators initiate cumulus expansion and cumulus oocyte complex detachment, whereas the follicular apex undergoes extensive extracellular matrix remodeling and a loss of the surface epithelium. The remainder of the follicle undergoes rapid angiogenesis and functional differentiation of granulosa and theca cells. Ultimately, these functional and structural changes culminate in follicular rupture and oocyte release. Throughout the ovulatory process, the importance of inflammatory responses is highlighted by the commonalities and similarities between many of these events associated with ovulation and inflammation. However, ovulation includes processes that are distinct from inflammation, such as regulation of steroid action, oocyte maturation, and the eventual release of the oocyte. This review focuses on the commonalities between inflammatory responses and the process of ovulation.

Original languageEnglish (US)
Pages (from-to)369-416
Number of pages48
JournalEndocrine reviews
Volume40
Issue number2
DOIs
StatePublished - Jan 1 2019

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Ovulation
Oocytes
Granulosa Cells
Theca Cells
Inflammation
Rupture
Ovary
Steroids
Chemokines
Basement Membrane
Prostaglandins
Extracellular Matrix
Epithelium
Endothelial Cells
Cytokines

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Duffy, D. M., Ko, C., Jo, M., Brannstrom, M., & Curry, T. E. (2019). Ovulation: Parallels with inflammatory processes. Endocrine reviews, 40(2), 369-416. https://doi.org/10.1210/er.2018-00075

Ovulation : Parallels with inflammatory processes. / Duffy, Diane M.; Ko, CheMyong; Jo, Misung; Brannstrom, Mats; Curry, Thomas E.

In: Endocrine reviews, Vol. 40, No. 2, 01.01.2019, p. 369-416.

Research output: Contribution to journalReview article

Duffy, DM, Ko, C, Jo, M, Brannstrom, M & Curry, TE 2019, 'Ovulation: Parallels with inflammatory processes', Endocrine reviews, vol. 40, no. 2, pp. 369-416. https://doi.org/10.1210/er.2018-00075
Duffy, Diane M. ; Ko, CheMyong ; Jo, Misung ; Brannstrom, Mats ; Curry, Thomas E. / Ovulation : Parallels with inflammatory processes. In: Endocrine reviews. 2019 ; Vol. 40, No. 2. pp. 369-416.
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