Ovarian follicle development and transgenic mouse models

K. R. Barnett, C. Schilling, C. R. Greenfeld, D. Tomic, J. A. Flaws

Research output: Contribution to journalReview articlepeer-review


Ovarian follicle development is a complex process that begins with the establishment of what is thought to be a finite pool of primordial follicles and culminates in either the atretic degradation of the follicle or the release of a mature oocyte for fertilization. This review highlights the many advances made in understanding these events using transgenic mouse models. Specifically, this review describes the ovarian phenotypes of mice with genetic mutations that affect ovarian differentiation, primordial follicle formation, follicular growth, atresia, ovulation and corpus luteum (CL) formation. In addition, this review describes the phenotypes of mice with mutations in a variety of genes, which affect the hormones that regulate folliculogenesis. Because studies using transgenic animals have revealed a variety of reproductive abnormalities that resemble many reproductive disorders in women, it is likely that studies using transgenic mouse models will impact our understanding of ovarian function and fertility in women.

Original languageEnglish (US)
Pages (from-to)537-555
Number of pages19
JournalHuman Reproduction Update
Issue number5
StatePublished - Sep 2006
Externally publishedYes


  • Follicle development
  • Ovary
  • Transgenic mouse models

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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