TY - JOUR
T1 - Oscillation-Based Connectivity Architecture Is Dominated by an Intrinsic Spatial Organization, Not Cognitive State or Frequency
AU - Mostame, Parham
AU - Sadaghiani, Sepideh
N1 - Publisher Copyright:
Copyright © 2021 the authors.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/1/6
Y1 - 2021/1/6
N2 - Functional connectivity of neural oscillations (oscillation-based FC) is thought to afford dynamic information exchange across task-relevant neural ensembles. Although oscillation-based FC is classically defined relative to a prestimulus baseline, giving rise to rapid, context-dependent changes in individual connections, studies of distributed spatial patterns show that oscillation- based FC is omnipresent, occurring even in the absence of explicit cognitive demands. Thus, the issue of whether oscillation- based FC is primarily shaped by cognitive state or is intrinsic in nature remains open. Accordingly, we sought to reconcile these observations by interrogating the ECoG recordings of 18 presurgical human patients (8 females) for state dependence of oscillation-based FC in five canonical frequency bands across an array of six task states. FC analysis of phase and amplitude coupling revealed a highly similar, largely state-invariant (i.e., intrinsic) spatial component across cognitive states. This spatial organization was shared across all frequency bands. Crucially, however, each band also exhibited temporally independent FC dynamics capable of supporting frequency-specific information exchange. In conclusion, the spatial organization of oscillation-based FC is largely stable over cognitive states (i.e., primarily intrinsic in nature) and shared across frequency bands. Together, our findings converge with previous observations of spatially invariant patterns of FC derived from extremely slow and aperiodic fluctuations in fMRI signals. Our observations indicate that "background"FC should be accounted for in conceptual frameworks of oscillation-based FC targeting task-related changes.
AB - Functional connectivity of neural oscillations (oscillation-based FC) is thought to afford dynamic information exchange across task-relevant neural ensembles. Although oscillation-based FC is classically defined relative to a prestimulus baseline, giving rise to rapid, context-dependent changes in individual connections, studies of distributed spatial patterns show that oscillation- based FC is omnipresent, occurring even in the absence of explicit cognitive demands. Thus, the issue of whether oscillation- based FC is primarily shaped by cognitive state or is intrinsic in nature remains open. Accordingly, we sought to reconcile these observations by interrogating the ECoG recordings of 18 presurgical human patients (8 females) for state dependence of oscillation-based FC in five canonical frequency bands across an array of six task states. FC analysis of phase and amplitude coupling revealed a highly similar, largely state-invariant (i.e., intrinsic) spatial component across cognitive states. This spatial organization was shared across all frequency bands. Crucially, however, each band also exhibited temporally independent FC dynamics capable of supporting frequency-specific information exchange. In conclusion, the spatial organization of oscillation-based FC is largely stable over cognitive states (i.e., primarily intrinsic in nature) and shared across frequency bands. Together, our findings converge with previous observations of spatially invariant patterns of FC derived from extremely slow and aperiodic fluctuations in fMRI signals. Our observations indicate that "background"FC should be accounted for in conceptual frameworks of oscillation-based FC targeting task-related changes.
KW - amplitude coupling
KW - electrocorticography
KW - functional connectivity
KW - intrinsic
KW - oscillations
KW - phase coupling
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U2 - 10.1523/JNEUROSCI.2155-20.2020
DO - 10.1523/JNEUROSCI.2155-20.2020
M3 - Article
C2 - 33203739
SN - 0270-6474
VL - 41
SP - 179
EP - 192
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
IS - 1
ER -