Organic Synthesis: Wherefrom and Whither? (Some Very Personal Reflections)

Research output: Contribution to journalArticle

Abstract

This perspective represents a (highly personal) examination of the past, present and future of synthetic organic chemistry. The central thesis posits that the confluence of factors that led to the “Golden Age of Natural Product Synthesis” in the second half of the twentieth century can be traced back to the identification of the therapeutic potential of steroid hormones culminating in the introduction of oral contraceptives. The tremendous benefits of those activities to the development of organic synthesis as a vibrant discipline led to the exponential increase in strategies and methods and the ability to tackle, larger and larger molecules of greater and greater complexity. The existential challenge to the health of organic synthesis is whether a similarly dynamic future can be anticipated and if so, to what end and how. Musings on potential answers to those questions are presented.

Original languageEnglish (US)
Pages (from-to)61-72
Number of pages12
JournalIsrael Journal of Chemistry
Volume58
Issue number1
DOIs
StatePublished - Feb 2018

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Steroid hormones
Oral Contraceptives
Biological Products
Health
Molecules
Organic Chemistry

Keywords

  • function
  • history
  • natural products
  • steroids
  • synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Organic Synthesis : Wherefrom and Whither? (Some Very Personal Reflections). / Denmark, Scott E.

In: Israel Journal of Chemistry, Vol. 58, No. 1, 02.2018, p. 61-72.

Research output: Contribution to journalArticle

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