ORChestra coordinates the replication and repair music

Dazhen Liu, Jay Sonalkar, Supriya G. Prasanth

Research output: Contribution to journalArticlepeer-review


Error-free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP-dependent manner, play critical roles in replisome assembly, and coordinate cell-cycle regulation. We discuss how the eukaryotic initiator, Origin recognition complex (ORC), coordinates different events during the cell cycle. We propose that ORC is the maestro driving the orchestra to coordinately perform the musical pieces of replication, chromatin organization, and repair.

Original languageEnglish (US)
Article number2200229
Issue number4
StatePublished - Apr 2023


  • DNA repair
  • DNA replication
  • ORC
  • cell cycle
  • chromatin
  • pre-replication complex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'ORChestra coordinates the replication and repair music'. Together they form a unique fingerprint.

Cite this