Oral leiomyosarcoma: Review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers

Nikolaos G. Nikitakis, Marcio A. Lopes, Jonathan S. Bailey, Remy H. Blanchaert, Robert A. Ord, John J. Sauk

Research output: Contribution to journalArticle

Abstract

Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalOral Oncology
Volume38
Issue number2
DOIs
StatePublished - Mar 4 2002
Externally publishedYes

Keywords

  • CDK4
  • Immunohistochemistry
  • Leiomyosarcoma
  • MDM2
  • Oral
  • PCNA
  • Real-time quantitative PCR
  • bcl-2
  • p53

ASJC Scopus subject areas

  • Oncology

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