Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats

M. Hoenig, E. T. Jordan, D. C. Ferguson, F. de Vries

Research output: Contribution to journalArticlepeer-review

Abstract

The response to oral glucose was examined in 10 obese and 9 lean age-matched, neutered cats. In all cats, oral administration of 2 g/kg glucose was followed by a prompt increase in glucose, insulin, and glucagon-like peptide (GLP)-1. There were significant differences between lean and obese cats in the areas under the curve for glucose, insulin, and GLP-1. However, the responses were variable, and a clear distinction between individual lean and obese cats was not possible. Therefore, this test cannot be recommended as a routine test to examine insulin resistance in individual cats as it is used in people. A further disadvantage for routine use is also the fact that this test requires gastric tubing for the correct administration of the glucose and associated tranquilization to minimize stress and that it was associated with development of diarrhea in 25% of the cats. GLP-1 concentrations were much lower in obese than lean cats. The low GLP-1 concentrations in obese cats might indicate a contribution of GLP-1 to the lower insulin sensitivity of obese cats, but this hypothesis needs to be further investigated.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalDomestic Animal Endocrinology
Volume38
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Glucose tolerance
  • Incretin
  • Insulin resistance
  • Insulin sensitivity
  • Obesity

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

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