Optimizing the design of FT-IR spectroscopic imaging instruments to obtain increased spatial resolution of chemical species

R. Reddy, D. Mayerich, M. Walsh, M. Schulmerich, P. S. Carney, R. Bhargava

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fourier transform infrared (FT-IR) spectroscopic imaging provides spatially resolved chemical information. Recent developments have shown that this chemical information can be used to determine tissue cell types. Our goal is then to use the spatial distribution of tissue cell types to perform accurate diagnosis of cancer. However, this step is limited by the spatial resolution provided by current imaging systems. In this paper, we demonstrate that these instruments can be designed to provide better spatial resolution for tissue chemistry. We present an optical model for the propagation of light through an FT-IR spectroscopic imaging system. Using this model, we minimally modify an existing FT-IR spectroscopic imaging system to obtain significantly higher resolution and image quality. We demonstrate that it is possible to identify previously obscured tissue types by performing histological classification based on bio-chemically derived spectral features (metrics).

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages354-357
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Reddy, R., Mayerich, D., Walsh, M., Schulmerich, M., Carney, P. S., & Bhargava, R. (2012). Optimizing the design of FT-IR spectroscopic imaging instruments to obtain increased spatial resolution of chemical species. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 354-357). [6235557] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2012.6235557