Optimization and generality of a small deoxyribozyme that ligates RNA

Keyphrases

• Deoxyribozyme 100%
• Ligate 100%
• 7Q10 100%
• Ligation 83%
• RNA Substrates 33%
• RNA Ligase 33%
• Nucleic Acids 16%
• Chemical Reaction 16%
• Pyrimidine 16%
• Purine 16%
• Practical Utility 16%
• Percentage Yield 16%
• Mutagenesis 16%
• Deprotonation 16%
• Rate-determining Step 16%
• Hydroxyl Group 16%
• Cyclic Phosphate 16%
• Mechanistic Understanding 16%
• Sequence Motif 16%
• Reaction Steps 16%
• Phosphodiester Bond 16%
• Large RNAs 16%
• In Vitro Evolution 16%
• RNA Ligation 16%
• Specific Degradation 16%
• Arrowhead 16%

Chemistry

• Catalytic DNA 100%
• Ribonucleic Acid 100%
• Purine 10%
• Nucleic Acid 10%
• Deprotonation 10%
• Hydroxyl Group 10%
• Reaction Step 10%
• formation 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Deoxyribozyme 100%
• RNA Ligase 40%
• Nucleic Acid 20%
• Hydroxyl Group 20%
• Purine 20%
• Mutagenesis 20%
• Arrowhead 20%
• Pyrimidine 20%