TY - JOUR
T1 - Optimal protein-folding codes from spin-glass theory
AU - Goldstein, Richard A.
AU - Luthey-Schulten, Zaida A.
AU - Wolynes, Peter G.
PY - 1992
Y1 - 1992
N2 - Protein-folding codes embodied in sequence-dependent energy functions can be optimized using spin-glass theory. Optimal folding codes for associative-memory Hamiltonians based on aligned sequences are deduced. A screening method based on these codes correctly recognizes protein structures in the "twilight zone" of sequence identity in the overwhelming majority of cases. Simulated annealing for the optimally encoded Hamiltonian generally leads to qualitatively correct structures.
AB - Protein-folding codes embodied in sequence-dependent energy functions can be optimized using spin-glass theory. Optimal folding codes for associative-memory Hamiltonians based on aligned sequences are deduced. A screening method based on these codes correctly recognizes protein structures in the "twilight zone" of sequence identity in the overwhelming majority of cases. Simulated annealing for the optimally encoded Hamiltonian generally leads to qualitatively correct structures.
KW - Associative memories
KW - Biomolecular dynamics
KW - Neural networks
KW - Protein-structure prediction
UR - http://www.scopus.com/inward/record.url?scp=0026663720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026663720&partnerID=8YFLogxK
U2 - 10.1073/pnas.89.11.4918
DO - 10.1073/pnas.89.11.4918
M3 - Article
C2 - 1594594
AN - SCOPUS:0026663720
SN - 0027-8424
VL - 89
SP - 4918
EP - 4922
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -