Abstract

Magnetomotive optical coherence tomgraphy (MMOCT) is a technique that has been introduced to pinpoint magnetic iron oxide nanoparticles within a standard OCT image, requiring only the addition of a small electromagnet to the imaging system. OCT, an emerging imaging technology, provides microscopic in vivo imaging by using interferometry to detect light reflected from deep tissue structures. The basic MMOCT technique involves querying the tissue both before and after application of the magnetic field gradient. Magnetomotive displacement depends on the elasticity and binding of the nanoparticle within the tissue microenvironment, which has potential applications for tissue elastography, and also measurement of particles binding to cell surface receptors. MMOCT thereby provides a unique platform for studying nanoparticle movement in vivo, with better depth penetration than in conventional microscopy.

Original languageEnglish
JournalOptics and Photonics News
Volume17
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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