Optically active nanoparticles for ultrasensitive detection and spectroscopy

Dustin J. Maxwell, John T. Krug, Shuming Nie

Research output: Contribution to journalConference articlepeer-review


Recent research in our lab has identified a new class of metal nanoparticles that are highly efficient for surface-enhanced optical spectroscopy. By coupling nanoparticles with surface-enhanced Raman scattering (SERS), surface optical processes can be enhanced by 14 to 15 orders of magnitude. This enormous enhancement allows the optical detection of single molecules at room temperature. However, in a standard silver colloid only 1 out of 100 nanoparticles is SERS-active. In this report, a new methodology based on size-selective filtration is demonstrated. This size-selective fractionation procedure yields an enriched colloid that can be used to prepare highly efficient nanoparticle thin films.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2000
Externally publishedYes
EventIn-Vitro Diagnostic Instrumentation - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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