Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

Chin Hong Tan, Kathy A. Low, Antonio M. Chiarelli, Mark A. Fletcher, Riccardo Navarra, Agnieszka Z. Burzynska, Tania S. Kong, Benjamin Zimmerman, Edward L. Maclin, Brad Sutton, Gabriele Gratton, Monica Fabiani

Research output: Contribution to journalArticle

Abstract

Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18–87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline.

Original languageEnglish (US)
JournalNeurobiology of Aging
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Vascular Stiffness
Aptitude
Elasticity
Pulse
White Matter
Optical Tomography
Middle Cerebral Artery
Cognition
Blood Vessels
Hypertension

Keywords

  • Aging
  • Arterial elasticity
  • Cerebrovascular health
  • Diffuse optical tomography (DOT)
  • Fluid abilities
  • Pulse-DOT

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging. / Tan, Chin Hong; Low, Kathy A.; Chiarelli, Antonio M.; Fletcher, Mark A.; Navarra, Riccardo; Burzynska, Agnieszka Z.; Kong, Tania S.; Zimmerman, Benjamin; Maclin, Edward L.; Sutton, Brad; Gratton, Gabriele; Fabiani, Monica.

In: Neurobiology of Aging, 01.01.2019.

Research output: Contribution to journalArticle

Tan, Chin Hong ; Low, Kathy A. ; Chiarelli, Antonio M. ; Fletcher, Mark A. ; Navarra, Riccardo ; Burzynska, Agnieszka Z. ; Kong, Tania S. ; Zimmerman, Benjamin ; Maclin, Edward L. ; Sutton, Brad ; Gratton, Gabriele ; Fabiani, Monica. / Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging. In: Neurobiology of Aging. 2019.
@article{a2bd0f43750644cca23823620309b6a6,
title = "Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging",
abstract = "Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18–87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline.",
keywords = "Aging, Arterial elasticity, Cerebrovascular health, Diffuse optical tomography (DOT), Fluid abilities, Pulse-DOT",
author = "Tan, {Chin Hong} and Low, {Kathy A.} and Chiarelli, {Antonio M.} and Fletcher, {Mark A.} and Riccardo Navarra and Burzynska, {Agnieszka Z.} and Kong, {Tania S.} and Benjamin Zimmerman and Maclin, {Edward L.} and Brad Sutton and Gabriele Gratton and Monica Fabiani",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2019.08.004",
language = "English (US)",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

AU - Tan, Chin Hong

AU - Low, Kathy A.

AU - Chiarelli, Antonio M.

AU - Fletcher, Mark A.

AU - Navarra, Riccardo

AU - Burzynska, Agnieszka Z.

AU - Kong, Tania S.

AU - Zimmerman, Benjamin

AU - Maclin, Edward L.

AU - Sutton, Brad

AU - Gratton, Gabriele

AU - Fabiani, Monica

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18–87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline.

AB - Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18–87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline.

KW - Aging

KW - Arterial elasticity

KW - Cerebrovascular health

KW - Diffuse optical tomography (DOT)

KW - Fluid abilities

KW - Pulse-DOT

UR - http://www.scopus.com/inward/record.url?scp=85071715995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071715995&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2019.08.004

DO - 10.1016/j.neurobiolaging.2019.08.004

M3 - Article

AN - SCOPUS:85071715995

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -