Optical coherence tomography of developing embryonic morphology

Stephen A. Boppart, Gary J. Tearney, Brett Bouma, James G. Fujimoto, Mark E. Brezinski

Research output: Contribution to journalConference articlepeer-review


Recent advances in molecular biology techniques have permitted the site specific insertion of predetermined mutations into embryos for the investigation of normal and abnormal development. Currently, there are several imaging modalities available to observe the expression of genetic mutations including light, confocal, and electron microscopy, but these typically require small, transparent, or fixed specimens. Optical coherence tomography (OCT) offers the ability to image in vivo developing morphology in many of the animal models used for genetic studies. In addition, OCT has the potential to rapidly and repeatedly acquire optical histology to assess development and to identify the expression of normal and abnormal genes.

Original languageEnglish (US)
Pages (from-to)55-56
Number of pages2
JournalConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 Conference on Lasers and Electro-Optics, CLEO'96 - Anaheim, CA, USA
Duration: Jun 2 1996Jun 7 1996

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


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