Abstract

Tissue engineering holds the promise for a therapeutic solution in regenerative medicine. The primary goal of tissue engineering is the development of physiologically functional and biocompatible tissues/organs being implanted for the repair and replacement of damaged or diseased ones. Given the complexity in the developing processes of engineered tissues, which involves multi-dimensional interactions among cells of different types, three-dimensionally constructed scaffolds, and actively intervening bioreactors, a capable real-time imaging tool is critically required for expanding our knowledge about the developing process of desired tissues or organs. It has been recognized that optical coherence tomography (OCT), an emerging noninvasive imaging technique that provides high spatial resolution (up to the cellular level) and three-dimensional imaging capability, is a promising investigative tool for tissue engineering. This chapter discusses the existing and potential applications of OCT in tissue engineering. Example OCT investigations of the three major components of tissue engineering, i.e., cells, scaffolds, and bioreactors are overviewed. Imaging examples of OCT and its enabling functions and variants, e.g., Doppler OCT, polarization-sensitive OCT, optical coherence microscopy are emphasized. Remaining challenges in the application of OCT to tissue engineering are discussed, and the prospective solutions including the combination of OCT with other high-contrast and high-resolution modalities such as two-photon fluorescence microscopy are suggested as well. It is expected that OCT, along with its functional variants, will make important contributions toward revealing the complex cellular dynamics in engineered tissues as well as help us culture demanding tissue/organ implants that will advance regenerative medicine.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Pages1965-2001
Number of pages37
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
DOIs
StatePublished - Jan 1 2015

Fingerprint

tissue engineering
Optical tomography
Optical Coherence Tomography
Tissue Engineering
Tissue engineering
tomography
Tissue
Imaging techniques
organs
Regenerative Medicine
bioreactors
Bioreactors
medicine
Tissue culture
microscopy
Three-Dimensional Imaging
Fluorescence microscopy
Bioelectric potentials
Scaffolds (biology)
high resolution

Keywords

  • Cellular imaging
  • Optical coherence tomography
  • Optical imaging
  • Regenerative medicine
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Zhao, Y., Yang, Y., Wang, R. K., & Boppart, S. A. (2015). Optical coherence tomography in tissue engineering. In Optical Coherence Tomography: Technology and Applications, Second Edition (pp. 1965-2001). Springer International Publishing. https://doi.org/10.1007/978-3-319-06419-2_64

Optical coherence tomography in tissue engineering. / Zhao, Youbo; Yang, Ying; Wang, Ruikang K.; Boppart, Stephen A.

Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. p. 1965-2001.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zhao, Y, Yang, Y, Wang, RK & Boppart, SA 2015, Optical coherence tomography in tissue engineering. in Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, pp. 1965-2001. https://doi.org/10.1007/978-3-319-06419-2_64
Zhao Y, Yang Y, Wang RK, Boppart SA. Optical coherence tomography in tissue engineering. In Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing. 2015. p. 1965-2001 https://doi.org/10.1007/978-3-319-06419-2_64
Zhao, Youbo ; Yang, Ying ; Wang, Ruikang K. ; Boppart, Stephen A. / Optical coherence tomography in tissue engineering. Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. pp. 1965-2001
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