Abstract

The mechanical properties of tissue are pivotal in its function and behavior, and are often modified by disease. From the nano- to the macro–scale, many tools have been developed to measure tissue mechanical properties, both to understand the contribution of mechanics in the origin of disease and to improve diagnosis. Optical coherence elastography is applicable to the intermediate scale, between that of cells and whole organs, which is critical in the progression of many diseases and not widely studied to date. In optical coherence elastography, a mechanical load is imparted to a tissue and the resulting deformation is measured using optical coherence tomography. The deformation is used to deduce a mechanical parameter, e.g., Young’s modulus, which is mapped into an image, known as an elastogram. In this chapter, we review the development of optical coherence elastography and report on the latest developments. We provide a focus on the underlying principles and assumptions, techniques to measure deformation, loading mechanisms, imaging probes and modeling, including the inverse elasticity problem.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Pages1007-1054
Number of pages48
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
DOIs
StatePublished - Jan 1 2015

Fingerprint

Elasticity Imaging Techniques
Tissue
Mechanical properties
Optical tomography
mechanical properties
Elastic Modulus
Elasticity
Optical Coherence Tomography
Mechanics
Elastic moduli
progressions
organs
Disease Progression
Imaging techniques
modulus of elasticity
elastic properties
tomography
probes
cells

Keywords

  • Biomechanics
  • Cell mechanics
  • Elastography
  • Optical elastography
  • Soft tissue
  • Tissue mechanics

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Kennedy, B. F., Kennedy, K. M., Oldenburg, A. L., Adie, S. G., Boppart, S. A., & Sampson, D. D. (2015). Optical coherence elastography. In Optical Coherence Tomography: Technology and Applications, Second Edition (pp. 1007-1054). Springer International Publishing. https://doi.org/10.1007/978-3-319-06419-2_32

Optical coherence elastography. / Kennedy, Brendan F.; Kennedy, Kelsey M.; Oldenburg, Amy L.; Adie, Steven G.; Boppart, Stephen A.; Sampson, David D.

Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. p. 1007-1054.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kennedy, BF, Kennedy, KM, Oldenburg, AL, Adie, SG, Boppart, SA & Sampson, DD 2015, Optical coherence elastography. in Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, pp. 1007-1054. https://doi.org/10.1007/978-3-319-06419-2_32
Kennedy BF, Kennedy KM, Oldenburg AL, Adie SG, Boppart SA, Sampson DD. Optical coherence elastography. In Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing. 2015. p. 1007-1054 https://doi.org/10.1007/978-3-319-06419-2_32
Kennedy, Brendan F. ; Kennedy, Kelsey M. ; Oldenburg, Amy L. ; Adie, Steven G. ; Boppart, Stephen A. ; Sampson, David D. / Optical coherence elastography. Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. pp. 1007-1054
@inbook{e25e11101d714b6fbae81aa0d18a4b73,
title = "Optical coherence elastography",
abstract = "The mechanical properties of tissue are pivotal in its function and behavior, and are often modified by disease. From the nano- to the macro–scale, many tools have been developed to measure tissue mechanical properties, both to understand the contribution of mechanics in the origin of disease and to improve diagnosis. Optical coherence elastography is applicable to the intermediate scale, between that of cells and whole organs, which is critical in the progression of many diseases and not widely studied to date. In optical coherence elastography, a mechanical load is imparted to a tissue and the resulting deformation is measured using optical coherence tomography. The deformation is used to deduce a mechanical parameter, e.g., Young’s modulus, which is mapped into an image, known as an elastogram. In this chapter, we review the development of optical coherence elastography and report on the latest developments. We provide a focus on the underlying principles and assumptions, techniques to measure deformation, loading mechanisms, imaging probes and modeling, including the inverse elasticity problem.",
keywords = "Biomechanics, Cell mechanics, Elastography, Optical elastography, Soft tissue, Tissue mechanics",
author = "Kennedy, {Brendan F.} and Kennedy, {Kelsey M.} and Oldenburg, {Amy L.} and Adie, {Steven G.} and Boppart, {Stephen A.} and Sampson, {David D.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-06419-2_32",
language = "English (US)",
isbn = "9783319064185",
pages = "1007--1054",
booktitle = "Optical Coherence Tomography",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Optical coherence elastography

AU - Kennedy, Brendan F.

AU - Kennedy, Kelsey M.

AU - Oldenburg, Amy L.

AU - Adie, Steven G.

AU - Boppart, Stephen A.

AU - Sampson, David D.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The mechanical properties of tissue are pivotal in its function and behavior, and are often modified by disease. From the nano- to the macro–scale, many tools have been developed to measure tissue mechanical properties, both to understand the contribution of mechanics in the origin of disease and to improve diagnosis. Optical coherence elastography is applicable to the intermediate scale, between that of cells and whole organs, which is critical in the progression of many diseases and not widely studied to date. In optical coherence elastography, a mechanical load is imparted to a tissue and the resulting deformation is measured using optical coherence tomography. The deformation is used to deduce a mechanical parameter, e.g., Young’s modulus, which is mapped into an image, known as an elastogram. In this chapter, we review the development of optical coherence elastography and report on the latest developments. We provide a focus on the underlying principles and assumptions, techniques to measure deformation, loading mechanisms, imaging probes and modeling, including the inverse elasticity problem.

AB - The mechanical properties of tissue are pivotal in its function and behavior, and are often modified by disease. From the nano- to the macro–scale, many tools have been developed to measure tissue mechanical properties, both to understand the contribution of mechanics in the origin of disease and to improve diagnosis. Optical coherence elastography is applicable to the intermediate scale, between that of cells and whole organs, which is critical in the progression of many diseases and not widely studied to date. In optical coherence elastography, a mechanical load is imparted to a tissue and the resulting deformation is measured using optical coherence tomography. The deformation is used to deduce a mechanical parameter, e.g., Young’s modulus, which is mapped into an image, known as an elastogram. In this chapter, we review the development of optical coherence elastography and report on the latest developments. We provide a focus on the underlying principles and assumptions, techniques to measure deformation, loading mechanisms, imaging probes and modeling, including the inverse elasticity problem.

KW - Biomechanics

KW - Cell mechanics

KW - Elastography

KW - Optical elastography

KW - Soft tissue

KW - Tissue mechanics

UR - http://www.scopus.com/inward/record.url?scp=84945156411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945156411&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-06419-2_32

DO - 10.1007/978-3-319-06419-2_32

M3 - Chapter

AN - SCOPUS:84945156411

SN - 9783319064185

SP - 1007

EP - 1054

BT - Optical Coherence Tomography

PB - Springer International Publishing

ER -