Optical characterization of contrast agents for optical coherence tomography

Tin Man Lee, Farah Jean Jacques Toublan, Amy Oldenburg, Shoeb Sitafalwalla, Wei Luo, Daniel L. Marks, Kenneth S Suslick, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of contrast agents in almost every imaging modality has been known to enhance the sensitivity of detection and improve diagnostic capabilities by site-specifically labeling tissues or cells of interest. The imaging capabilities of Optical Coherence Tomography (OCT) need to be improved in order to detect early neoplastic changes in medicine and tumor biology. We introduce and characterize the optical properties of several types of optical contrast agents in OCT, namely encapsulating microspheres that incorporate materials including melanin, gold, and carbon. Micron-sized microspheres have been fabricated by state-of-the-art sonicating and ultrasound technology. The optical properties of optical contrast agents have been characterized according to their scattering and absorption coefficients and lifetimes using OCT and the oblique incidence reflectometry method. Finally, we demonstrate the use of these optical contrast agents in in vitro mice liver and analyze the contrast improvement from the OCT images. These optical contrast agents have the potential to improve the detection of in vivo pathologies in the future.

Original languageEnglish (US)
Title of host publicationProc. SPIE
Subtitle of host publicationGenetically Engineered and Optical Probes for Biomedical Applications
PublisherSPIE
Pages129-134
Number of pages6
Volume4967
DOIs
StatePublished - 2003

Fingerprint

Optical tomography
tomography
Microspheres
Optical properties
Melanin
Imaging techniques
melanin
optical properties
Pathology
encapsulating
Liver
Labeling
scattering coefficients
pathology
Medicine
Tumors
biology
medicine
liver
Gold

Keywords

  • Absorption coefficients
  • Contrast agents
  • Microspheres
  • OCT
  • Scattering

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lee, T. M., Toublan, F. J. J., Oldenburg, A., Sitafalwalla, S., Luo, W., Marks, D. L., ... Boppart, S. A. (2003). Optical characterization of contrast agents for optical coherence tomography. In Proc. SPIE: Genetically Engineered and Optical Probes for Biomedical Applications (Vol. 4967, pp. 129-134). SPIE. https://doi.org/10.1117/12.478396

Optical characterization of contrast agents for optical coherence tomography. / Lee, Tin Man; Toublan, Farah Jean Jacques; Oldenburg, Amy; Sitafalwalla, Shoeb; Luo, Wei; Marks, Daniel L.; Suslick, Kenneth S; Boppart, Stephen A.

Proc. SPIE: Genetically Engineered and Optical Probes for Biomedical Applications. Vol. 4967 SPIE, 2003. p. 129-134.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, TM, Toublan, FJJ, Oldenburg, A, Sitafalwalla, S, Luo, W, Marks, DL, Suslick, KS & Boppart, SA 2003, Optical characterization of contrast agents for optical coherence tomography. in Proc. SPIE: Genetically Engineered and Optical Probes for Biomedical Applications. vol. 4967, SPIE, pp. 129-134. https://doi.org/10.1117/12.478396
Lee TM, Toublan FJJ, Oldenburg A, Sitafalwalla S, Luo W, Marks DL et al. Optical characterization of contrast agents for optical coherence tomography. In Proc. SPIE: Genetically Engineered and Optical Probes for Biomedical Applications. Vol. 4967. SPIE. 2003. p. 129-134 https://doi.org/10.1117/12.478396
Lee, Tin Man ; Toublan, Farah Jean Jacques ; Oldenburg, Amy ; Sitafalwalla, Shoeb ; Luo, Wei ; Marks, Daniel L. ; Suslick, Kenneth S ; Boppart, Stephen A. / Optical characterization of contrast agents for optical coherence tomography. Proc. SPIE: Genetically Engineered and Optical Probes for Biomedical Applications. Vol. 4967 SPIE, 2003. pp. 129-134
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