Opposite effects of interleukin-2 and interleukin-4 on GABA-induced inward currents of dialysed lymnaea neurons

Katalin S. Rózsa, Stanislav S. Rubakhin, Attila Szücs, Thomas K. Hughes, George B. Stefano

Research output: Contribution to journalArticlepeer-review

Abstract

1. The effects of interleukin 2 (rhIL-2) and interleukin-4 (rhIL-4) were investigated on γ-aminobutyric acid (GABA)-induced inward currents on isolated, identified neurons of Lymnaea stagnalis L. (Mollusca, Gastropoda) by using a concentration clamp technique. 2. It was shown that the interleukins modified the GABA-induced inward current in an opposite direction: rhIL-2 (2-100 U/ml) decreased the peak value of I(GABA in a dose-dependent manner, whereas rhIL-4 (0.2-100 U/ml), on the contrary, potentiated it. Both types of modulation were partially or fully reversible. 3. The reversal potential of I(GABA) was not shifted by these cytokines. 4. The time to peak value and inactivation time constant of the γ-aminobutyric acid (GABA) in duced current was decreased by rhIL-4. The modulatory effect of rhIL-4 was eliminated after conjuga tion of this cytokine with its antibody. 5. It appears that cytokines could play a role in regulating the neural excitability through GABAerg mechanisms.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalGeneral Pharmacology
Volume29
Issue number1
DOIs
StatePublished - Jul 1 1997
Externally publishedYes

Keywords

  • Interleukin-2
  • Interleukin-4
  • Lymnaea stagnalis
  • γ-aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Pharmacology

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