Ontogeny of uterine responsiveness to estrogen during early development in the rat

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1. 1. Uterine responsiveness to exogenous estradiol was studied in rats of 5-23 days of age in terms of several known estrogen-dependent parameters - induction of the synthesis of a specific uterine estrogen-induced protein, IP, and increased glucose metabolism, two temporally early responses to estrogen, and increased uterine weight at 1 day and at 3 days after hormone, two later estrogen-induced responses. 2. 2. Induced protein (IP) synthesis can be induced, and induced nearly maximally on a per cell basis in uteri of day 5 rats. The IP to DNA ratio remains nearly constant from day 5 through day 15-18 and drops at day 23. At all ages, IP represents 1.6-3.1% of the newly labeled soluble uterine protein. 3. 3. In contrast to the early uterine responsiveness in terms of IP synthesis, maximal stimulation of 2-deoxyglucose metabolism is not obtained until day 12-15 and maximal increases in the 24 h estradiol-induced uterine wet weight are not obtained until day 12. Likewise, a maximal 3 day uterine growth response cannot be induced until day 20 although some minimal response can be obtained to the 3 daily injections even in the day 5 uterus. 4. 4. These studies indicate that the uterus can respond partially to exogenous estrogen very early (by day 5), but that full responsiveness develops over a further period of approximately two weeks. Further, the induction of IP synthesis is itself not sufficient for induction of the full complement of responses culminating in uterine growth.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalMolecular and Cellular Endocrinology
Issue number1
StatePublished - Dec 1974


  • deoxyglucose metabolism
  • estrogen
  • induced protein
  • uterine development

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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