One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction

Matthew J. Mio, Lucas C. Kopel, Julia B. Braun, Tendai L. Gadzikwa, Kami L. Hull, Ronald G. Brisbois, Christopher J. Markworth, Paul A. Grieco

Research output: Contribution to journalArticlepeer-review

Abstract

equation presented A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.

Original languageEnglish (US)
Pages (from-to)3199-3202
Number of pages4
JournalOrganic Letters
Volume4
Issue number19
DOIs
StatePublished - Sep 19 2002

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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