One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction

Matthew J. Mio; Lucas C. Kopel; Julia B. Braun; Tendai L. Gadzikwa; Kami L. Hull; Ronald G. Brisbois; Christopher J. Markworth; Paul A. Grieco

doi:10.1021/ol026266n

One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction

Matthew J. Mio, Lucas C. Kopel, Julia B. Braun, Tendai L. Gadzikwa, Kami L. Hull, Ronald G. Brisbois, Christopher J. Markworth, Paul A. Grieco

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

equation presented A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.

Original language	English (US)
Pages (from-to)	3199-3202
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	19
DOIs	https://doi.org/10.1021/ol026266n
State	Published - Sep 19 2002

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol026266n

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One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction. / Mio, Matthew J.; Kopel, Lucas C.; Braun, Julia B.; Gadzikwa, Tendai L.; Hull, Kami L.; Brisbois, Ronald G.; Markworth, Christopher J.; Grieco, Paul A.

In: Organic Letters, Vol. 4, No. 19, 19.09.2002, p. 3199-3202.

Research output: Contribution to journal › Article › peer-review

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abstract = "equation presented A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.",

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AU - Gadzikwa, Tendai L.

AU - Hull, Kami L.

AU - Brisbois, Ronald G.

AU - Markworth, Christopher J.

AU - Grieco, Paul A.

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