The stereochemical course of the intramolecular allylsilane‐aldehyde condensation of 1a has been investigated. A modest preference for the product arising from a synclinal orientation of double bonds was observed with Lewis‐acid catalysts. Cyclization induced by fluoride ion resulted in stereochemical reversal.
ASJC Scopus subject areas
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry