TY - JOUR
T1 - On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase
AU - Whitteck, John T.
AU - Malova, Petra
AU - Peck, Spencer C.
AU - Cicchillo, Robert M.
AU - Hammerschmidt, Friedrich
AU - Van Der Donk, Wilfred A.
PY - 2011/3/30
Y1 - 2011/3/30
N2 - Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated.
AB - Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated.
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U2 - 10.1021/ja1113326
DO - 10.1021/ja1113326
M3 - Article
C2 - 21381767
AN - SCOPUS:79953045737
SN - 0002-7863
VL - 133
SP - 4236
EP - 4239
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 12
ER -