On the regioselectivity of thioether formation by lacticin 481 synthetase

Xingang Zhang, Weijuan Ni, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


Lantibiotic synthetases generate intramolecular thioether cross-links within peptides through the Michael-type addition of cysteines onto dehydroamino acids originating from Ser and Thr. Presented here is an assay that readily distinguishes between enzymatic and nonenzymatic formation of these cross-links. The results demonstrate unequivocally that lacticin 481 synthetase can generate non-native thioether cross-links.

Original languageEnglish (US)
Pages (from-to)3343-3346
Number of pages4
JournalOrganic Letters
Issue number17
StatePublished - Aug 16 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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