On the origin of enzymatic species

Gregory A. Petsko, George L. Kenyon, John A. Gerlt, Dagmar Ringe, John W. Kozarich

Research output: Contribution to journalArticlepeer-review


The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalTrends in Biochemical Sciences
Issue number10
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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