On the origin of enzymatic species

Gregory A. Petsko; George L. Kenyon; John A. Gerlt; Dagmar Ringe; John W. Kozarich

doi:10.1016/0968-0004(93)90091-Z

On the origin of enzymatic species

Gregory A. Petsko, George L. Kenyon, John A. Gerlt, Dagmar Ringe, John W. Kozarich

Research output: Contribution to journal › Article › peer-review

Abstract

The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding.

Original language	English (US)
Pages (from-to)	372-376
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/0968-0004(93)90091-Z
State	Published - Oct 1993
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0968-0004(93)90091-Z

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AU - Kozarich, John W.

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On the origin of enzymatic species

Abstract

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