Abstract
Free of bias: Preorganization is not a requirement for the efficient cyclization of the erythromycin core, as has always been assumed. This finding has enabled Ci-H oxidative cyclization or Yamaguchi macrocyclization to form stereochemically modified erythromycin structures that were previously inaccessible by using the traditional biasing element approach (see scheme; PG=protecting group).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2094-2097 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 9 |
| DOIs | |
| State | Published - Feb 25 2011 |
Keywords
- Ci-H oxidation
- cyclization
- erythromycin
- lactonization
- natural products
ASJC Scopus subject areas
- Catalysis
- General Chemistry