Free of bias: Preorganization is not a requirement for the efficient cyclization of the erythromycin core, as has always been assumed. This finding has enabled Ci-H oxidative cyclization or Yamaguchi macrocyclization to form stereochemically modified erythromycin structures that were previously inaccessible by using the traditional biasing element approach (see scheme; PG=protecting group).
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Feb 25 2011|
- Ci-H oxidation
- natural products
ASJC Scopus subject areas