Abstract
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent-greatgrandchild and cousin relationships are used as examples to illustrate our methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-200 |
| Number of pages | 10 |
| Journal | Journal of Computational Biology |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |
Keywords
- Gamete
- Genomic data
- Identity by descent
- Markov process
- Relationship inference
ASJC Scopus subject areas
- Modeling and Simulation
- Molecular Biology
- Genetics
- Computational Mathematics
- Computational Theory and Mathematics