On relationship inference using gamete identity by descent data

Hongyu Zhao, Feng Liang

Research output: Contribution to journalArticlepeer-review

Abstract

Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent-greatgrandchild and cousin relationships are used as examples to illustrate our methods.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalJournal of Computational Biology
Volume8
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Gamete
  • Genomic data
  • Identity by descent
  • Markov process
  • Relationship inference

ASJC Scopus subject areas

  • Modeling and Simulation
  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics

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