TY - GEN
T1 - On MR experiment design with quadratic regularization
AU - Haldar, Justin P.
AU - Liang, Zhi-Pei
PY - 2011/11/2
Y1 - 2011/11/2
N2 - The design of MRI experiments represents a trade-off between acquisition time, signal-to-noise ratio (SNR), and resolution. For fixed acquisition time and reconstruction resolution, it has been widely believed that the optimal acquisition strategy is to avoid collecting k-space data at frequencies higher than the nominal image resolution. While this belief is true under certain metrics, we observe in this work that a high-resolution acquisition strategy, combined with an appropriate linear filtering/regularization strategy, leads to significantly improved SNR/resolution efficiency for the majority of common resolution metrics. Analysis of this surprising result leads to practical methods for the improved design of imaging experiments and the selection of efficient quadratic regularization penalties.
AB - The design of MRI experiments represents a trade-off between acquisition time, signal-to-noise ratio (SNR), and resolution. For fixed acquisition time and reconstruction resolution, it has been widely believed that the optimal acquisition strategy is to avoid collecting k-space data at frequencies higher than the nominal image resolution. While this belief is true under certain metrics, we observe in this work that a high-resolution acquisition strategy, combined with an appropriate linear filtering/regularization strategy, leads to significantly improved SNR/resolution efficiency for the majority of common resolution metrics. Analysis of this surprising result leads to practical methods for the improved design of imaging experiments and the selection of efficient quadratic regularization penalties.
KW - Experiment Design
KW - Magnetic Resonance Imaging
KW - Regularization
KW - Resolution
UR - http://www.scopus.com/inward/record.url?scp=80055056889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055056889&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872726
DO - 10.1109/ISBI.2011.5872726
M3 - Conference contribution
AN - SCOPUS:80055056889
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1676
EP - 1679
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -