TY - GEN
T1 - On modeling gene regulatory networks using markov random fields
AU - Santhanam, Narayana
AU - Dingel, Janis
AU - Milenkovic, Olgiça
PY - 2009
Y1 - 2009
N2 - Modeling the joint expression patterns of genes is a challenging task due to the large number of genes simultaneously studied, relative to the amount of microarray data available. To model the joint expression profiles of genes using a small number of observations, we use Ising models to approximate the joint expression profiles. This approach naturally lends itself to the study of gene interactions and has a close connection to clustering techniques, which we use to reconstruct E. coli gene interaction pathways from microarray data. In addition, we note that extending available partial network topology information can be done using very few microarray samples-logarithmic in the number of genes.
AB - Modeling the joint expression patterns of genes is a challenging task due to the large number of genes simultaneously studied, relative to the amount of microarray data available. To model the joint expression profiles of genes using a small number of observations, we use Ising models to approximate the joint expression profiles. This approach naturally lends itself to the study of gene interactions and has a close connection to clustering techniques, which we use to reconstruct E. coli gene interaction pathways from microarray data. In addition, we note that extending available partial network topology information can be done using very few microarray samples-logarithmic in the number of genes.
UR - http://www.scopus.com/inward/record.url?scp=77950672924&partnerID=8YFLogxK
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U2 - 10.1109/ITWNIT.2009.5158562
DO - 10.1109/ITWNIT.2009.5158562
M3 - Conference contribution
AN - SCOPUS:77950672924
SN - 9781424445363
T3 - Proceedings - 2009 IEEE Information Theory Workshop on Networking and Information Theory, ITW 2009
SP - 156
EP - 160
BT - Proceedings - 2009 IEEE Information Theory Workshop on Networking and Information Theory, ITW 2009
T2 - 2009 IEEE Information Theory Workshop on Networking and Information Theory, ITW 2009
Y2 - 10 June 2009 through 12 June 2009
ER -