TY - JOUR
T1 - On Hallucinations in Tomographic Image Reconstruction
AU - Bhadra, Sayantan
AU - Kelkar, Varun A.
AU - Brooks, Frank J.
AU - Anastasio, Mark A.
N1 - Funding Information:
Manuscript received March 26, 2021; revised April 28, 2021; accepted April 28, 2021. Date of publication May 5, 2021; date of current version October 27, 2021. This work was supported in part by the National Institutes of Health (NIH) Awards under Grant EB020604, Grant EB023045, Grant NS102213, and Grant EB028652; and in part by the National Science Foundation (NSF) Award under Grant DMS1614305. (Sayantan Bhadra and Varun A. Kelkar contributed equally to this work.) (Corresponding author: Mark A. Anastasio.) Sayantan Bhadra is with the Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130 USA (e-mail: [email protected]).
Publisher Copyright:
© 1982-2012 IEEE.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies.
AB - Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies.
KW - Tomographic image reconstruction
KW - deep learning
KW - hallucinations
KW - image quality assessment
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U2 - 10.1109/TMI.2021.3077857
DO - 10.1109/TMI.2021.3077857
M3 - Article
C2 - 33950837
AN - SCOPUS:85105893372
SN - 0278-0062
VL - 40
SP - 3249
EP - 3260
JO - IEEE transactions on medical imaging
JF - IEEE transactions on medical imaging
IS - 11
ER -