Olfactory bulb mitral cell dendritic pruning abnormalities in a mouse model of the Fragile-X mental retardation syndrome: Further support for FMRP's involvement in dendritic development

Roberto Galvez, Rebecca Lynn Smith, William T. Greenough

Research output: Contribution to journalArticle

Abstract

The Fragile-X mental retardation syndrome is the leading form of inherited mental retardation. Dendritic analysis in a mouse model (FraX) found abnormal pruning in somatosensory cortex. To further characterize dendritic abnormalities and assess their occurrence in other brain regions, we examined mitral cells in FraX mice olfactory bulbs. FraX mice exhibited dendritic abnormalities consistent with somatosensory cortex, suggesting that deficient pruning is found in multiple brain regions.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalDevelopmental Brain Research
Volume157
Issue number2
DOIs
StatePublished - Jun 30 2005

Keywords

  • Dendritic pruning
  • Development
  • FMRP
  • Fragile X
  • Olfactory bulb
  • fmr1

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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