Old and new approaches to target the hsp90 chaperone

Keyphrases

• Hsp90 Inhibitor 100%
• Chaperone Hsp90 100%
• Heat Shock Protein 90 (Hsp90) 83%
• Clinical Trials 33%
• Client Proteins 33%
• Anticancer 16%
• Phosphorylation 16%
• Monotherapy 16%
• N-terminal Domain 16%
• Clinical Outcomes 16%
• Cancer Disease 16%
• Amino-terminus 16%
• Carboxy Terminal Domain 16%
• Tumor Progression 16%
• Pharmacokinetic Profile 16%
• Clinical Research 16%
• Neurodegenerative Diseases 16%
• Healthy Cells 16%
• Chaperone 16%
• Molecular Chaperone 16%
• Cellular Stress 16%
• Cancer Cell Death 16%
• Preclinical Research 16%
• Protein Inhibition 16%
• Dose-limiting Toxicity 16%
• Druggable Targets 16%
• Isoform-selective Inhibitor 16%
• Cellular Proteostasis 16%
• Protein Maintenance 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Chaperone 100%
• Heat Shock Protein 90 Inhibitor 100%
• Malignant Neoplasm 60%
• Clinical Trial 60%
• Monotherapy 20%
• Tumor Growth 20%
• Clinical Research 20%
• Degenerative Disease 20%
• Heat Shock Protein 90 20%
• Pharmacokinetic 20%

Biochemistry, Genetics and Molecular Biology

• Hsp90 100%
• Hsp90 Inhibitor 71%
• Clinical Trial 42%
• N-Terminus 28%
• Isoform 14%
• C-Terminus 14%
• Tumor Progression 14%
• Cancer Cell 14%
• Pharmacokinetics 14%
• Heat Shock Protein 14%
• Cell Death 14%
• Anticancer 14%
• Protein Homeostasis 14%
• Cell Stress 14%
• Clinical Research 14%
• Chaperone Protein 14%