Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

Hui Lin Ong; Adela Maria Isvoranu; Frederike Schirmbeck; Philip McGuire; Lucia Valmaggia; Matthew J. Kempton; Mark Van Der Gaag; Anita Riecher-Rössler; Rodrigo A. Bressan; Neus Barrantes-Vidal; Barnaby Nelson; G. Paul Amminger; Patrick McGorry; Christos Pantelis; Marie Odile Krebs; Merete Nordentoft; Birte Glenthøj; Stephan Ruhrmann; Gabriele Sachs; Bart P.F. Rutten; Jim Van Os; Lieuwe De Haan; Denny Borsboom; Maria Calem; Stefania Tognin; Gemma Modinos; Sara Pisani; Emily Hedges; Eva Velthorst; Tamar C. Kraan; Daniella S. Van Dam; Nadine Burger; Athena Politis; Joanne Goodall; Stefan Borgwardt; Erich Studerus; Ary Gadelha; Elisa Brietzke; Graccielle Asevedo; Elson Asevedo; Andre Zugman; Tecelli Domínguez-Martínez; Manel Monsonet; Lidia Hinojosa; Anna Racioppi; Thomas R. Kwapil; Mathilde Kazes; Claire Daban; Julie Bourgin; Olivier Gay; Célia Mam-Lam-Fook; Dorte Nordholm; Lasse Randers; Kristine Krakauer; Louise Birkedal Glenthøj; Dominika Gebhard; Julia Arnhold; Joachim Klosterkötter; Iris Lasser; Bernadette Winklbaur; Philippe A. Delespaul

doi:10.1093/schbul/sbaa187

Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

Hui Lin Ong, Adela Maria Isvoranu, Frederike Schirmbeck, Philip McGuire, Lucia Valmaggia, Matthew J. Kempton, Mark Van Der Gaag, Anita Riecher-Rössler, Rodrigo A. Bressan, Neus Barrantes-Vidal, Barnaby Nelson, G. Paul Amminger, Patrick McGorry, Christos Pantelis, Marie Odile Krebs, Merete Nordentoft, Birte Glenthøj, Stephan Ruhrmann, Gabriele Sachs, Bart P.F. RuttenJim Van Os, Lieuwe De Haan, Denny Borsboom, Maria Calem, Stefania Tognin, Gemma Modinos, Sara Pisani, Emily Hedges, Eva Velthorst, Tamar C. Kraan, Daniella S. Van Dam, Nadine Burger, Athena Politis, Joanne Goodall, Stefan Borgwardt, Erich Studerus, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Tecelli Domínguez-Martínez, Manel Monsonet, Lidia Hinojosa, Anna Racioppi, Thomas R. Kwapil, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Célia Mam-Lam-Fook, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Birkedal Glenthøj, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Iris Lasser, Bernadette Winklbaur, Philippe A. Delespaul

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

Original language	English (US)
Pages (from-to)	1018-1028
Number of pages	11
Journal	Schizophrenia Bulletin
Volume	47
Issue number	4
DOIs	https://doi.org/10.1093/schbul/sbaa187
State	Published - Jul 1 2021

Keywords

anxiety
clinical high risk
depression
network analysis
obsessive-compulsive
psychosis
ultra-high risk

ASJC Scopus subject areas

Psychiatry and Mental health

Online availability

10.1093/schbul/sbaa187

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Ong, H. L., Isvoranu, A. M., Schirmbeck, F., McGuire, P., Valmaggia, L., Kempton, M. J., Van Der Gaag, M., Riecher-Rössler, A., Bressan, R. A., Barrantes-Vidal, N., Nelson, B., Amminger, G. P., McGorry, P., Pantelis, C., Krebs, M. O., Nordentoft, M., Glenthøj, B., Ruhrmann, S., Sachs, G., ... Delespaul, P. A. (2021). Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective. Schizophrenia Bulletin, 47(4), 1018-1028. https://doi.org/10.1093/schbul/sbaa187

Ong, HL, Isvoranu, AM, Schirmbeck, F, McGuire, P, Valmaggia, L, Kempton, MJ, Van Der Gaag, M, Riecher-Rössler, A, Bressan, RA, Barrantes-Vidal, N, Nelson, B, Amminger, GP, McGorry, P, Pantelis, C, Krebs, MO, Nordentoft, M, Glenthøj, B, Ruhrmann, S, Sachs, G, Rutten, BPF, Van Os, J, De Haan, L, Borsboom, D, Calem, M, Tognin, S, Modinos, G, Pisani, S, Hedges, E, Velthorst, E, Kraan, TC, Van Dam, DS, Burger, N, Politis, A, Goodall, J, Borgwardt, S, Studerus, E, Gadelha, A, Brietzke, E, Asevedo, G, Asevedo, E, Zugman, A, Domínguez-Martínez, T, Monsonet, M, Hinojosa, L, Racioppi, A, Kwapil, TR, Kazes, M, Daban, C, Bourgin, J, Gay, O, Mam-Lam-Fook, C, Nordholm, D, Randers, L, Krakauer, K, Glenthøj, LB, Gebhard, D, Arnhold, J, Klosterkötter, J, Lasser, I, Winklbaur, B & Delespaul, PA 2021, 'Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective', Schizophrenia Bulletin, vol. 47, no. 4, pp. 1018-1028. https://doi.org/10.1093/schbul/sbaa187

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title = "Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective",

abstract = "Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.",

keywords = "anxiety, clinical high risk, depression, network analysis, obsessive-compulsive, psychosis, ultra-high risk",

author = "Ong, {Hui Lin} and Isvoranu, {Adela Maria} and Frederike Schirmbeck and Philip McGuire and Lucia Valmaggia and Kempton, {Matthew J.} and {Van Der Gaag}, Mark and Anita Riecher-R{\"o}ssler and Bressan, {Rodrigo A.} and Neus Barrantes-Vidal and Barnaby Nelson and Amminger, {G. Paul} and Patrick McGorry and Christos Pantelis and Krebs, {Marie Odile} and Merete Nordentoft and Birte Glenth{\o}j and Stephan Ruhrmann and Gabriele Sachs and Rutten, {Bart P.F.} and {Van Os}, Jim and {De Haan}, Lieuwe and Denny Borsboom and Maria Calem and Stefania Tognin and Gemma Modinos and Sara Pisani and Emily Hedges and Eva Velthorst and Kraan, {Tamar C.} and {Van Dam}, {Daniella S.} and Nadine Burger and Athena Politis and Joanne Goodall and Stefan Borgwardt and Erich Studerus and Ary Gadelha and Elisa Brietzke and Graccielle Asevedo and Elson Asevedo and Andre Zugman and Tecelli Dom{\'i}nguez-Mart{\'i}nez and Manel Monsonet and Lidia Hinojosa and Anna Racioppi and Kwapil, {Thomas R.} and Mathilde Kazes and Claire Daban and Julie Bourgin and Olivier Gay and C{\'e}lia Mam-Lam-Fook and Dorte Nordholm and Lasse Randers and Kristine Krakauer and Glenth{\o}j, {Louise Birkedal} and Dominika Gebhard and Julia Arnhold and Joachim Klosterk{\"o}tter and Iris Lasser and Bernadette Winklbaur and Delespaul, {Philippe A.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.",

year = "2021",

month = jul,

day = "1",

doi = "10.1093/schbul/sbaa187",

language = "English (US)",

volume = "47",

pages = "1018--1028",

journal = "Schizophrenia Bulletin",

issn = "0586-7614",

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number = "4",

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TY - JOUR

T1 - Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis

T2 - A Network Perspective

AU - Ong, Hui Lin

AU - Isvoranu, Adela Maria

AU - Schirmbeck, Frederike

AU - McGuire, Philip

AU - Valmaggia, Lucia

AU - Kempton, Matthew J.

AU - Van Der Gaag, Mark

AU - Riecher-Rössler, Anita

AU - Bressan, Rodrigo A.

AU - Barrantes-Vidal, Neus

AU - Nelson, Barnaby

AU - Amminger, G. Paul

AU - McGorry, Patrick

AU - Pantelis, Christos

AU - Krebs, Marie Odile

AU - Nordentoft, Merete

AU - Glenthøj, Birte

AU - Ruhrmann, Stephan

AU - Sachs, Gabriele

AU - Rutten, Bart P.F.

AU - Van Os, Jim

AU - De Haan, Lieuwe

AU - Borsboom, Denny

AU - Calem, Maria

AU - Tognin, Stefania

AU - Modinos, Gemma

AU - Pisani, Sara

AU - Hedges, Emily

AU - Velthorst, Eva

AU - Kraan, Tamar C.

AU - Van Dam, Daniella S.

AU - Burger, Nadine

AU - Politis, Athena

AU - Goodall, Joanne

AU - Borgwardt, Stefan

AU - Studerus, Erich

AU - Gadelha, Ary

AU - Brietzke, Elisa

AU - Asevedo, Graccielle

AU - Asevedo, Elson

AU - Zugman, Andre

AU - Domínguez-Martínez, Tecelli

AU - Monsonet, Manel

AU - Hinojosa, Lidia

AU - Racioppi, Anna

AU - Kwapil, Thomas R.

AU - Kazes, Mathilde

AU - Daban, Claire

AU - Bourgin, Julie

AU - Gay, Olivier

AU - Mam-Lam-Fook, Célia

AU - Nordholm, Dorte

AU - Randers, Lasse

AU - Krakauer, Kristine

AU - Glenthøj, Louise Birkedal

AU - Gebhard, Dominika

AU - Arnhold, Julia

AU - Klosterkötter, Joachim

AU - Lasser, Iris

AU - Winklbaur, Bernadette

AU - Delespaul, Philippe A.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

AB - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

KW - anxiety

KW - clinical high risk

KW - depression

KW - network analysis

KW - obsessive-compulsive

KW - psychosis

KW - ultra-high risk

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DO - 10.1093/schbul/sbaa187

M3 - Article

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AN - SCOPUS:85111024453

SN - 0586-7614

VL - 47

SP - 1018

EP - 1028

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

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ER -

Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

Abstract

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