Observing on the Stratospheric Observatory for Infrared Astronomy (SOFIA) requires a strategy that takes the specific circumstances of an airborne platform into account. Observations of a source cannot be extended or shortened on the spot due to flight path constraints. Still, no exact prediction of the time on source is available since there are always wind and weather conditions, and sometimes technical issues. Observations have to be planned to maximize the observing efficiency while maintaining full flexibility for changes during the observation. The complex nature of observations with FIFI-LS-such as the interlocking cycles of the mechanical gratings, telescope nodding and dithering-is considered in the observing strategy as well. Since SOFIA Cycle 3 FIFI-LS is available to general investigators. Therefore general investigators must be able to define the necessary parameters simply, without being familiar with the instrument, still resulting in efficient and flexible observations. We describe the observing process with FIFI-LS including the integration time estimate, the mapping and dithering setup and aspects of the scripting for the actual observations performed in flight. We also give an overview of the observing scenarios, which have proven to be useful for FIFI-LS.