Observation of strange kinetics in protein folding

J. Sabelko, J. Ervin, M. Gruebele

Research output: Contribution to journalArticlepeer-review


Highly nonexponential folding kinetics in aqueous solution have been observed during temperature jump-induced refolding of two proteins, yeast phosphoglycerate kinase and a ubiquitin mutant. The observations are most easily interpreted in terms of downhill folding, which posits a heterogeneous ensemble of structures en route to the folded state. The data are also reconciled with exponential kinetics measured under different experimental conditions and with titration experiments indicating cooperative folding.

Original languageEnglish (US)
Pages (from-to)6031-6036
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number11
StatePublished - May 25 1999

ASJC Scopus subject areas

  • General


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