Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

Rachel E. Klaren, Elizabeth A. Hubbard, Nathan C. Wetter, Bradley P. Sutton, Robert W. Motl

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).

METHODS: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.

RESULTS: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.

CONCLUSION: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalNeurodegenerative disease management
Volume7
Issue number1
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Keywords

  • brain volumetrics
  • multiple sclerosis
  • sedentary behavior patterns

ASJC Scopus subject areas

  • Medicine(all)

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