Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

Rachel E. Klaren; Elizabeth A. Hubbard; Nathan C. Wetter; Bradley P. Sutton; Robert W. Motl

doi:10.2217/nmt-2016-0036

Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

Rachel E. Klaren, Elizabeth A. Hubbard, Nathan C. Wetter, Bradley P. Sutton, Robert W. Motl

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).

METHODS: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.

RESULTS: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.

CONCLUSION: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.

Original language	English (US)
Pages (from-to)	31-37
Number of pages	7
Journal	Neurodegenerative disease management
Volume	7
Issue number	1
DOIs	https://doi.org/10.2217/nmt-2016-0036
State	Published - Feb 1 2017
Externally published	Yes

Keywords

brain volumetrics
multiple sclerosis
sedentary behavior patterns

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.2217/nmt-2016-0036

Cite this

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title = "Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis",

abstract = "AIM: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).METHODS: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.RESULTS: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.CONCLUSION: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.",

keywords = "brain volumetrics, multiple sclerosis, sedentary behavior patterns",

author = "Klaren, {Rachel E.} and Hubbard, {Elizabeth A.} and Wetter, {Nathan C.} and Sutton, {Bradley P.} and Motl, {Robert W.}",

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doi = "10.2217/nmt-2016-0036",

language = "English (US)",

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journal = "Neurodegenerative disease management",

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T1 - Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

AU - Klaren, Rachel E.

AU - Hubbard, Elizabeth A.

AU - Wetter, Nathan C.

AU - Sutton, Bradley P.

AU - Motl, Robert W.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - AIM: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).METHODS: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.RESULTS: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.CONCLUSION: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.

AB - AIM: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).METHODS: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.RESULTS: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.CONCLUSION: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.

KW - brain volumetrics

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Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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