Obesity alters the muscle protein synthetic response to nutrition and exercise

Joseph W. Beals, Nicholas A. Burd, Daniel R. Moore, Stephan van Vliet

Research output: Contribution to journalReview article

Abstract

Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling by primarily stimulating protein synthesis rates. However, the muscle of individuals with obesity appears to be resistant to the anabolic action of targeted exercise regimes and protein ingestion when compared to normal-weight adults. This indicates impaired muscle protein remodeling in response to the main anabolic stimuli to human skeletal muscle tissue is contributing to poor muscle health with obesity. Deranged anabolic signaling related to insulin resistance, lipid accumulation, and/or systemic/muscle inflammation are likely at the root of the anabolic resistance of muscle protein synthesis rates with obesity. The purpose of this review is to discuss the impact of protein ingestion and exercise on muscle protein remodeling in people with obesity, and the potential mechanisms underlining anabolic resistance of their muscle.

Original languageEnglish (US)
Article number87
JournalFrontiers in Nutrition
Volume6
DOIs
StatePublished - Jun 13 2019

Fingerprint

Muscle Proteins
muscle protein
exercise
obesity
Obesity
nutrition
Muscles
skeletal muscle
Skeletal Muscle
physical activity
muscles
Proteins
muscle tissues
Eating
protein synthesis
ingestion
high protein diet
Health
protein metabolism
insulin resistance

Keywords

  • Anabolic resistance
  • Exercise
  • Fat mass
  • Inflammation
  • MTORC1
  • Muscle mass
  • P70S6K
  • TLR4

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Obesity alters the muscle protein synthetic response to nutrition and exercise. / Beals, Joseph W.; Burd, Nicholas A.; Moore, Daniel R.; van Vliet, Stephan.

In: Frontiers in Nutrition, Vol. 6, 87, 13.06.2019.

Research output: Contribution to journalReview article

Beals, Joseph W. ; Burd, Nicholas A. ; Moore, Daniel R. ; van Vliet, Stephan. / Obesity alters the muscle protein synthetic response to nutrition and exercise. In: Frontiers in Nutrition. 2019 ; Vol. 6.
@article{b4d9ec3d3f4541f2956b75d2971055e6,
title = "Obesity alters the muscle protein synthetic response to nutrition and exercise",
abstract = "Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling by primarily stimulating protein synthesis rates. However, the muscle of individuals with obesity appears to be resistant to the anabolic action of targeted exercise regimes and protein ingestion when compared to normal-weight adults. This indicates impaired muscle protein remodeling in response to the main anabolic stimuli to human skeletal muscle tissue is contributing to poor muscle health with obesity. Deranged anabolic signaling related to insulin resistance, lipid accumulation, and/or systemic/muscle inflammation are likely at the root of the anabolic resistance of muscle protein synthesis rates with obesity. The purpose of this review is to discuss the impact of protein ingestion and exercise on muscle protein remodeling in people with obesity, and the potential mechanisms underlining anabolic resistance of their muscle.",
keywords = "Anabolic resistance, Exercise, Fat mass, Inflammation, MTORC1, Muscle mass, P70S6K, TLR4",
author = "Beals, {Joseph W.} and Burd, {Nicholas A.} and Moore, {Daniel R.} and {van Vliet}, Stephan",
year = "2019",
month = "6",
day = "13",
doi = "10.3389/fnut.2019.00087",
language = "English (US)",
volume = "6",
journal = "Frontiers in Nutrition",
issn = "2296-861X",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Obesity alters the muscle protein synthetic response to nutrition and exercise

AU - Beals, Joseph W.

AU - Burd, Nicholas A.

AU - Moore, Daniel R.

AU - van Vliet, Stephan

PY - 2019/6/13

Y1 - 2019/6/13

N2 - Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling by primarily stimulating protein synthesis rates. However, the muscle of individuals with obesity appears to be resistant to the anabolic action of targeted exercise regimes and protein ingestion when compared to normal-weight adults. This indicates impaired muscle protein remodeling in response to the main anabolic stimuli to human skeletal muscle tissue is contributing to poor muscle health with obesity. Deranged anabolic signaling related to insulin resistance, lipid accumulation, and/or systemic/muscle inflammation are likely at the root of the anabolic resistance of muscle protein synthesis rates with obesity. The purpose of this review is to discuss the impact of protein ingestion and exercise on muscle protein remodeling in people with obesity, and the potential mechanisms underlining anabolic resistance of their muscle.

AB - Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling by primarily stimulating protein synthesis rates. However, the muscle of individuals with obesity appears to be resistant to the anabolic action of targeted exercise regimes and protein ingestion when compared to normal-weight adults. This indicates impaired muscle protein remodeling in response to the main anabolic stimuli to human skeletal muscle tissue is contributing to poor muscle health with obesity. Deranged anabolic signaling related to insulin resistance, lipid accumulation, and/or systemic/muscle inflammation are likely at the root of the anabolic resistance of muscle protein synthesis rates with obesity. The purpose of this review is to discuss the impact of protein ingestion and exercise on muscle protein remodeling in people with obesity, and the potential mechanisms underlining anabolic resistance of their muscle.

KW - Anabolic resistance

KW - Exercise

KW - Fat mass

KW - Inflammation

KW - MTORC1

KW - Muscle mass

KW - P70S6K

KW - TLR4

UR - http://www.scopus.com/inward/record.url?scp=85067834862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067834862&partnerID=8YFLogxK

U2 - 10.3389/fnut.2019.00087

DO - 10.3389/fnut.2019.00087

M3 - Review article

AN - SCOPUS:85067834862

VL - 6

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

SN - 2296-861X

M1 - 87

ER -