Nutritional supplementation boosts aerobic exercise effects on functional brain systems

Michelle W. Voss, Matthew Sutterer, Timothy B. Weng, Agnieszka Z. Burzynska, Jason Fanning, Elizabeth Salerno, Neha Pravin Gothe, Diane K. Ehlers, Edward McAuley, Arthur F. Kramer

Research output: Contribution to journalArticle

Abstract

There is growing evidence that aerobic exercise protects against age-related cognitive decline and that cardiorespiratory fitness is an important factor for these benefits. Studies also suggest that combining physical activity with cognitive enrichment is beneficial. We further examine these predictions by comparing effects of a nutritional supplement promoting exercise capacity to a lower-intensity activity with cognitive enrichment on functional network and cognitive outcomes that otherwise decline with aging. Inactive healthy older adults were randomized to one of four groups including a low-intensity activity with complex cognitive demands (dancing), walking, walkingsupplement, or an active control. Results showed that walkingsupplement increased salience network functional connectivity (FC), with less training benefit for default mode network FC. Although cognitive performance did not increase for any training group, participants in the walkingsupplement group who were on medication that boosted key neurotransmitters (e.g., selective serotonin reuptake inhibitors) showed improved processing speed. Overall, this study provides new insight into how to boost the protective effects of exercise on brain systems that otherwise deteriorate with aging.

Original languageEnglish (US)
Pages (from-to)77-87
Number of pages11
JournalJournal of Applied Physiology
Volume126
Issue number1
DOIs
StatePublished - Jan 2019

Fingerprint

Serotonin Uptake Inhibitors
Walking
Neurotransmitter Agents
Exercise
Brain
Cardiorespiratory Fitness
Cognitive Dysfunction

Keywords

  • Aging
  • Cardiorespiratory fitness
  • Default mode network
  • Functional connectivity
  • Physical activity
  • Randomized controlled trial
  • Salience network

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Voss, M. W., Sutterer, M., Weng, T. B., Burzynska, A. Z., Fanning, J., Salerno, E., ... Kramer, A. F. (2019). Nutritional supplementation boosts aerobic exercise effects on functional brain systems. Journal of Applied Physiology, 126(1), 77-87. https://doi.org/10.1152/japplphysiol.00917.2017

Nutritional supplementation boosts aerobic exercise effects on functional brain systems. / Voss, Michelle W.; Sutterer, Matthew; Weng, Timothy B.; Burzynska, Agnieszka Z.; Fanning, Jason; Salerno, Elizabeth; Gothe, Neha Pravin; Ehlers, Diane K.; McAuley, Edward; Kramer, Arthur F.

In: Journal of Applied Physiology, Vol. 126, No. 1, 01.2019, p. 77-87.

Research output: Contribution to journalArticle

Voss, MW, Sutterer, M, Weng, TB, Burzynska, AZ, Fanning, J, Salerno, E, Gothe, NP, Ehlers, DK, McAuley, E & Kramer, AF 2019, 'Nutritional supplementation boosts aerobic exercise effects on functional brain systems', Journal of Applied Physiology, vol. 126, no. 1, pp. 77-87. https://doi.org/10.1152/japplphysiol.00917.2017
Voss, Michelle W. ; Sutterer, Matthew ; Weng, Timothy B. ; Burzynska, Agnieszka Z. ; Fanning, Jason ; Salerno, Elizabeth ; Gothe, Neha Pravin ; Ehlers, Diane K. ; McAuley, Edward ; Kramer, Arthur F. / Nutritional supplementation boosts aerobic exercise effects on functional brain systems. In: Journal of Applied Physiology. 2019 ; Vol. 126, No. 1. pp. 77-87.
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