Nutritional immunity beyond iron: a role for manganese and zinc

Thomas E. Kehl-Fie, Eric P. Skaar

Research output: Contribution to journalReview articlepeer-review

Abstract

Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a variety of factors to steal iron from the host. Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection. Intracellularly, vertebrates utilize the ZIP/ZnT families of transporters to manipulate zinc levels, as well as Nramp1 to manipulate manganese levels. Extracellularly, the S100 protein calprotectin sequesters manganese and potentially zinc to inhibit microbial growth. To circumvent these defenses, bacteria possess high affinity transporters to import specific nutrient metals. Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume14
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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