@article{2492c1ba52e4466f819720ef459f06c9,
title = "Nutrigenetic contributions to dyslipidemia: A focus on physiologically relevant pathways of lipid and lipoprotein metabolism",
abstract = "Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.",
keywords = "Dyslipidemia, Lipids, Nutrigenetics",
author = "Hannon, {Bridget A.} and Khan, {Naiman A.} and Margarita Teran-Garcia",
note = "Funding Information: B.A.H. and M.T.G. are supported by the Agriculture and Food Research Initiative Competitive Grant no. 2015-68001-23248 from the USDA National Institute of Food and Agriculture to Cooperative Extension and the Department of Human Development and Family Studies at the University of Illinois at Urbana-Champaign. Support for this work also comes from Hatch Projects #ILLU-971-368, #ILLU-793-327, and the Department of Kinesiology and Community Health at the University of Illinois at Urbana-Champaign. Funding Information: Funding: B.A.H. and M.T.G. are supported by the Agriculture and Food Research Initiative Competitive Grant no. 2015-68001-23248 from the USDA National Institute of Food and Agriculture to Cooperative Extension and the Department of Human Development and Family Studies at the University of Illinois at Urbana-Champaign. Support for this work also comes from Hatch Projects #ILLU-971-368, #ILLU-793-327, and the Department of Kinesiology and Community Health at the University of Illinois at Urbana-Champaign. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = oct,
day = "2",
doi = "10.3390/nu10101404",
language = "English (US)",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",
}