Nutrigenetic contributions to dyslipidemia: A focus on physiologically relevant pathways of lipid and lipoprotein metabolism

Bridget A. Hannon; Naiman A. Khan; Margarita Teran-Garcia

doi:10.3390/nu10101404

Nutrigenetic contributions to dyslipidemia: A focus on physiologically relevant pathways of lipid and lipoprotein metabolism

Bridget A. Hannon, Naiman A. Khan, Margarita Teran-Garcia

Research output: Contribution to journal › Review article › peer-review

Abstract

Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.

Original language	English (US)
Article number	1404
Journal	Nutrients
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/nu10101404
State	Published - Oct 2 2018

Keywords

Dyslipidemia
Lipids
Nutrigenetics

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Access to Document

10.3390/nu10101404

Fingerprint Dive into the research topics of 'Nutrigenetic contributions to dyslipidemia: A focus on physiologically relevant pathways of lipid and lipoprotein metabolism'. Together they form a unique fingerprint.

Cite this

@article{2492c1ba52e4466f819720ef459f06c9,

title = "Nutrigenetic contributions to dyslipidemia: A focus on physiologically relevant pathways of lipid and lipoprotein metabolism",

abstract = "Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.",

keywords = "Dyslipidemia, Lipids, Nutrigenetics",

author = "Hannon, {Bridget A.} and Khan, {Naiman A.} and Margarita Teran-Garcia",

note = "Funding Information: Funding: B.A.H. and M.T.G. are supported by the Agriculture and Food Research Initiative Competitive Grant no. 2015-68001-23248 from the USDA National Institute of Food and Agriculture to Cooperative Extension and the Department of Human Development and Family Studies at the University of Illinois at Urbana-Champaign. Support for this work also comes from Hatch Projects #ILLU-971-368, #ILLU-793-327, and the Department of Kinesiology and Community Health at the University of Illinois at Urbana-Champaign.",

year = "2018",

month = oct,

day = "2",

doi = "10.3390/nu10101404",

language = "English (US)",

volume = "10",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - Nutrigenetic contributions to dyslipidemia

T2 - A focus on physiologically relevant pathways of lipid and lipoprotein metabolism

AU - Hannon, Bridget A.

AU - Khan, Naiman A.

AU - Teran-Garcia, Margarita

N1 - Funding Information: Funding: B.A.H. and M.T.G. are supported by the Agriculture and Food Research Initiative Competitive Grant no. 2015-68001-23248 from the USDA National Institute of Food and Agriculture to Cooperative Extension and the Department of Human Development and Family Studies at the University of Illinois at Urbana-Champaign. Support for this work also comes from Hatch Projects #ILLU-971-368, #ILLU-793-327, and the Department of Kinesiology and Community Health at the University of Illinois at Urbana-Champaign.

PY - 2018/10/2

Y1 - 2018/10/2

N2 - Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.

AB - Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.

KW - Dyslipidemia

KW - Lipids

KW - Nutrigenetics

UR - http://www.scopus.com/inward/record.url?scp=85054408624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054408624&partnerID=8YFLogxK

U2 - 10.3390/nu10101404

DO - 10.3390/nu10101404

M3 - Review article

C2 - 30279335

AN - SCOPUS:85054408624

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 1404

ER -