Abstract
Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.
| Original language | English (US) |
|---|---|
| Article number | 1404 |
| Journal | Nutrients |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2 2018 |
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Keywords
- Dyslipidemia
- Lipids
- Nutrigenetics
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
Cite this
Nutrigenetic contributions to dyslipidemia : A focus on physiologically relevant pathways of lipid and lipoprotein metabolism. / Hannon, Bridget A.; Khan, Naiman A; Teran-Garcia, Margarita De L.
In: Nutrients, Vol. 10, No. 10, 1404, 02.10.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nutrigenetic contributions to dyslipidemia
T2 - A focus on physiologically relevant pathways of lipid and lipoprotein metabolism
AU - Hannon, Bridget A.
AU - Khan, Naiman A
AU - Teran-Garcia, Margarita De L
PY - 2018/10/2
Y1 - 2018/10/2
N2 - Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.
AB - Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.
KW - Dyslipidemia
KW - Lipids
KW - Nutrigenetics
UR - http://www.scopus.com/inward/record.url?scp=85054408624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054408624&partnerID=8YFLogxK
U2 - 10.3390/nu10101404
DO - 10.3390/nu10101404
M3 - Review article
C2 - 30279335
AN - SCOPUS:85054408624
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 10
M1 - 1404
ER -