Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega-3 PUFAs

Tanveer Talukdar, Marta K. Zamroziewicz, Christopher E. Zwilling, Aron Keith Barbey

Research output: Contribution to journalArticle

Abstract

A wealth of neuroscience evidence demonstrates that diet and nutrition play an important role in structural brain plasticity, promoting the development of gray matter volume and maintenance of white matter integrity across the lifespan. However, the role of nutrition in shaping individual differences in the functional brain connectome remains to be well established. We therefore investigated whether nutrient biomarkers known to have beneficial effects on brain structure (i.e., the omega-3 polyunsaturated fatty acids; ω-3 PUFAs), explain individual differences in functional brain connectivity within healthy older adults (N = 96). Our findings demonstrate that ω-3 PUFAs are associated with individual differences in functional connectivity within regions that support executive function (prefrontal cortex), memory (hippocampus), and emotion (amygdala), and provide key evidence that the influence of these regions on global network connectivity reliably predict general, fluid, and crystallized intelligence. The observed findings not only elucidate the role of ω-3 PUFAs in functional brain plasticity and intelligence, but also motivate future studies to examine their impact on psychological health, aging, and disease.

Original languageEnglish (US)
Pages (from-to)1887-1897
Number of pages11
JournalHuman Brain Mapping
Volume40
Issue number6
DOIs
StatePublished - Apr 15 2019

Fingerprint

Individuality
Biomarkers
Food
Brain
Intelligence
Connectome
Executive Function
Omega-3 Fatty Acids
Neurosciences
Amygdala
Prefrontal Cortex
Unsaturated Fatty Acids
Hippocampus
Emotions
Maintenance
Psychology
Diet
Health

Keywords

  • functional brain connectivity
  • general intelligence
  • individual differences
  • omega-3 polyunsaturated fatty acids

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Nutrient biomarkers shape individual differences in functional brain connectivity : Evidence from omega-3 PUFAs. / Talukdar, Tanveer; Zamroziewicz, Marta K.; Zwilling, Christopher E.; Barbey, Aron Keith.

In: Human Brain Mapping, Vol. 40, No. 6, 15.04.2019, p. 1887-1897.

Research output: Contribution to journalArticle

Talukdar, Tanveer ; Zamroziewicz, Marta K. ; Zwilling, Christopher E. ; Barbey, Aron Keith. / Nutrient biomarkers shape individual differences in functional brain connectivity : Evidence from omega-3 PUFAs. In: Human Brain Mapping. 2019 ; Vol. 40, No. 6. pp. 1887-1897.
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