TY - JOUR
T1 - Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project
T2 - structure and function of the Rif‐Str regions
AU - Honoré, N.
AU - Bergh, S.
AU - Chanteau, S.
AU - Doucet‐Populaire, F.
AU - Eiglmeir, K.
AU - Garnier, T.
AU - Georges, C.
AU - Launois, P.
AU - Limpaiboon, T.
AU - Newton, S.
AU - Niang, K.
AU - del Portillo, P.
AU - Ramesh, G. R.
AU - Reddi, P.
AU - Ridel, P. R.
AU - Sittisombut, N.
AU - Wu‐Hunte, S.
AU - Cole, S. T.
PY - 1993/1
Y1 - 1993/1
N2 - The nucleotide sequence of cosmid B1790, carrying the Rif‐Str regions of the Mycobacterium leprae chromosome, has been determined. Twelve open reading frames were identified in the 36716bp sequence, representing 40% of the coding capacity. Five ribosomal proteins, two elongation factors and the β and β'subunits of RNA polymerase have been characterized and two novel genes were found. One of these encodes a member of the so‐called ABC family of ATP‐binding proteins while the other appears to encode an enzyme involved in repairing genomic lesions caused by free radicals. This finding may well be significant as M. leprae, an intracellular pathogen, lives within macrophages.
AB - The nucleotide sequence of cosmid B1790, carrying the Rif‐Str regions of the Mycobacterium leprae chromosome, has been determined. Twelve open reading frames were identified in the 36716bp sequence, representing 40% of the coding capacity. Five ribosomal proteins, two elongation factors and the β and β'subunits of RNA polymerase have been characterized and two novel genes were found. One of these encodes a member of the so‐called ABC family of ATP‐binding proteins while the other appears to encode an enzyme involved in repairing genomic lesions caused by free radicals. This finding may well be significant as M. leprae, an intracellular pathogen, lives within macrophages.
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U2 - 10.1111/j.1365-2958.1993.tb01112.x
DO - 10.1111/j.1365-2958.1993.tb01112.x
M3 - Article
C2 - 8446028
AN - SCOPUS:0027514523
SN - 0950-382X
VL - 7
SP - 207
EP - 214
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 2
ER -